Interaction #1 PRLR - FBXW11
(1) DEG_SCF_TRCP1_1 motif (348DSGRGS353) in Prolactin receptor (PRLR)
(2) WD domain, G-beta repeat (232-266) and (270-306) and (310-346) and (353-389) and (393-429) and (433-469) and (482-518) in F-box/WD repeat-containing protein 11 (FBXW11)
PTM-dependent Induction (Phosphorylation of S349 and S353 on Prolactin receptor (PRLR)) of the Prolactin receptor (PRLR) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 11 (FBXW11) WD domain, G-beta repeat interaction
(1) Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase.
Other switches involving participants