Switches.ELM

Switch #:

SWTI000161

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions

Interaction #1 ATF4 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (₂₁₈DSGICMS₂₂₄) in Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
(2) WD domain, G-beta repeat_(297-329) and _(333-369) and _(373-409) and _(416-452) and _(456-492) and _(496-532) and _(545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₂₁₉ and S₂₂₄ on Cyclic AMP-dependent transcription factor ATF-4 (ATF4)) of the Cyclic AMP-dependent transcription factor ATF-4 (ATF4) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context

Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol

References

(1) ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.
Lassot et al. Mol. Cell. Biol. (2001)