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Switch #:
SWTI000161
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions
Interaction #1 ATF4 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (218DSGICMS224) in Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S219 and S224 on Cyclic AMP-dependent transcription factor ATF-4 (ATF4)) of the Cyclic AMP-dependent transcription factor ATF-4 (ATF4) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context
References

(1) ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.
Lassot et al. Mol. Cell. Biol. (2001)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)




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