Switches.ELM

Switch #:

SWTI000162

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S927 and S932 in the TrCP1-binding motif of Nuclear factor NF-kappa-B p105 subunit (NFKB1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Nuclear factor NF-kappa-B p105 subunit (NFKB1)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions

Interaction #1 NFKB1 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (₉₂₆DSGVETS₉₃₂) in Nuclear factor NF-kappa-B p105 subunit (NFKB1)
(2) WD domain, G-beta repeat_(297-329) and _(333-369) and _(373-409) and _(416-452) and _(456-492) and _(496-532) and _(545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₉₂₇ and S₉₃₂ on Nuclear factor NF-kappa-B p105 subunit (NFKB1)) of the Nuclear factor NF-kappa-B p105 subunit (NFKB1) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₉₂₇ : IKK_group, Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB), Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK). S₉₃₂ : Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK), Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB).

Context

Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol

Inferred: cytosol

References

(1) betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
Lang et al. Mol. Cell. Biol. (2003)