Description:
Dual phosphorylation of S32 and S36 in the TrCP1-binding motif of NF-kappa-B inhibitor alpha (NFKBIA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation. Participants:
(1) NF-kappa-B inhibitor alpha (NFKBIA)
(2) F-box/WD repeat-containing protein 1A (BTRC)
Interaction #1 NFKBIA - BTRCInterfaces (1) DEG_SCF_TRCP1_1 motif ( 31DSGLDS36) in NF-kappa-B inhibitor alpha (NFKBIA)(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)Interaction Regulation PTM-dependent Induction (Phosphorylation of S32 and S36 on NF-kappa-B inhibitor alpha (NFKBIA)) of the NF-kappa-B inhibitor alpha (NFKBIA) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction Inferred Regulatory Enzymes for switchPutative modifying enzymes for residue: S32 : CK2_group, IKK_group, Casein kinase II subunit alpha (CSNK2A1), Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK), Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB), Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE), Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), Ribosomal protein S6 kinase alpha-3 (RPS6KA3), Serine/threonine-protein kinase Sgk1 (SGK1), Ribosomal protein S6 kinase alpha-1 (RPS6KA1). S36 : CK2_group, IKK_group, Casein kinase II subunit alpha (CSNK2A1), Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK), Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB), Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE), Mitogen-activated protein kinase kinase kinase 14 (MAP3K14).
(1) The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Winston et al. Genes Dev. (1999)
(2) Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.
Tan et al. Mol. Cell (1999)
(3) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.
Shirane et al. J. Biol. Chem. (1999) Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)
Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)
| |
Loading visualisation
|
