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Switch #:
SWTI000164
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S598 and S602 in the TrCP1-binding motif of Disks large homolog 1 (DLG1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Disks large homolog 1 (DLG1)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions
Interaction #1 DLG1 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (597DSGLPS602) in Disks large homolog 1 (DLG1)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S598 and S602 on Disks large homolog 1 (DLG1)) of the Disks large homolog 1 (DLG1) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context
Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
Inferred: nucleus, cytosol
References

(1) Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor.
Mantovani et al. J. Biol. Chem. (2003)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)
Disks large homolog 1 (DLG1) - 2 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)


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