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Switch #:
SWTI000165
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S19 and S23 in the TrCP1-binding motif of NF-kappa-B inhibitor beta (NFKBIB) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) NF-kappa-B inhibitor beta (NFKBIB)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions
Interaction #1 NFKBIB - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (18DSGLGS23) in NF-kappa-B inhibitor beta (NFKBIB)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S19 and S23 on NF-kappa-B inhibitor beta (NFKBIB)) of the NF-kappa-B inhibitor beta (NFKBIB) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S19 : Ribosomal protein S6 kinase alpha-1 (RPS6KA1). S23 : Ribosomal protein S6 kinase alpha-1 (RPS6KA1).

Context
Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
Inferred: cytosol, nucleus
References

(1) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.
Shirane et al. J. Biol. Chem. (1999)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)


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