Switches.ELM

Switch #:

SWTI000166

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S71 and S76 in the TrCP1-binding motif of Programmed cell death protein 4 (PDCD4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Programmed cell death protein 4 (PDCD4)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions

Interaction #1 PDCD4 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (₇₀DSGRGDS₇₆) in Programmed cell death protein 4 (PDCD4)
(2) WD domain, G-beta repeat_(297-329) and _(333-369) and _(373-409) and _(416-452) and _(456-492) and _(496-532) and _(545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₇₁ and S₇₆ on Programmed cell death protein 4 (PDCD4)) of the Programmed cell death protein 4 (PDCD4) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context

Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol

Inferred: cytosol, nucleus

References

(1) S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Dorrello et al. Science (2006)