Switch #: SWTI000239

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (Ap2s1) subunit for recruitment of T-cell surface glycoprotein CD3 gamma chain (Cd3g) via an endocytosis motif.

Participants:
(1) T-cell surface glycoprotein CD3 gamma chain (Cd3g)
(2) AP-2 complex subunit sigma (Ap2s1)

(1) A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.
Letourneur et al. Cell (1992)

(2) Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.
Dietrich et al. J. Cell Biol. (1997)

(3) Masking of the CD3 gamma di-leucine-based motif by zeta is required for efficient T-cell receptor expression.
Lauritsen et al. Traffic (2004)

Other switches involving participants
AP-2 complex subunit sigma (Ap2s1) - 2 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)