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Switch #:
SWTI000240
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of CD44 antigen (CD44) via an endocytosis motif.

Participants:
(1) CD44 antigen (CD44)
(2) AP-2 complex subunit sigma (AP2S1)

Interactions
Interaction #1 CD44 - AP2S1

Interfaces
(1) TRG_LysEnd_APsAcLL_1 motif (708EMVHLV713) in CD44 antigen (CD44)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)

Interaction Regulation
Effector binding Induction (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the CD44 antigen (CD44) TRG_LysEnd_APsAcLL_1 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction

Context
Switch localisation
ELM curated: Endocytic vesicle, cytosol
References

(1) A di-hydrophobic Leu-Val motif regulates the basolateral localization of CD44 in polarized Madin-Darby canine kidney epithelial cells.
Sheikh et al. J. Biol. Chem. (1996)

See also

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)


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