Switch #: SWTI000241

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Delta-type opioid receptor (OPRD1) via an endocytosis motif.

Participants:
(1) Delta-type opioid receptor (OPRD1)
(2) AP-2 complex subunit sigma (AP2S1)

(1) The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells.
Wang et al. J. Biol. Chem. (2003)

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)