Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Basal cell adhesion molecule (BCAM) via an endocytosis motif.
Participants: (1) Basal cell adhesion molecule (BCAM) (2) AP-2 complex subunit sigma (AP2S1)
(1) Isoforms of the Lutheran/basal cell adhesion molecule glycoprotein are differentially delivered in polarized epithelial cells. Mapping of the basolateral sorting signal to a cytoplasmic di-leucine motif.El Nemer et al. J. Biol. Chem. (1999)
Other switches involving participantsAP-2 complex subunit sigma (AP2S1) - 11 more (view)Other switches involving interfacesTRG_LysEnd_APsAcLL_1 - 14 more (view)Clathrin adaptor complex small chain - 15 more (view)
