Switch #: SWTI000292

Switch type: Specificity

Switch subtype: Altered binding specificity

Description:
Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).

Participants:
(1) Amyloid beta A4 protein (APP)
(2) Amyloid beta A4 precursor protein-binding family B member 1 (APBB1)
(3) Growth factor receptor-bound protein 2 (GRB2)

(1) The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.
Tamayev et al. Mol Neurodegener (2009)

(2) Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.
Zhou et al. J. Alzheimers Dis. (2009)

Other switches involving participants
Amyloid beta A4 protein (APP) - 2 more (view)
Amyloid beta A4 precursor protein-binding family B member 1 (APBB1) - 1 more (view)
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)
LIG_SH2_GRB2 - 6 more (view)
LIG_PTB_Apo_2 - 3 more (view)