Switch #: SWTI000293

Switch type: Specificity

Switch subtype: Altered binding specificity

Description:
Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1).

Participants:
(1) Integrin beta-3 (ITGB3)
(2) Fermitin family homolog 2 (FERMT2)
(3) SHC-transforming protein 1 (SHC1)

(1) Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.
Bledzka et al. J. Biol. Chem. (2010)

(2) Kindlin-2 (Mig-2): a co-activator of beta3 integrins.
Ma et al. J. Cell Biol. (2008)

(3) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh et al. J. Biol. Chem. (2010)

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Integrin beta-3 (ITGB3) - 15 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)
LIG_PTB_Apo_2 - 3 more (view)