Switch #: SWTI000327

Switch type: Specificity

Switch subtype: Domain hiding

Description:
An intramolecular interaction of the C-terminal PDZ binding motif of Amyloid beta A4 precursor protein-binding family A member 1 (APBA1) (also known as X11alpha/Mint1) with the PDZ domain tandem of APBA1 results in an auto-inhibited conformation of APBA1, where binding of ligands containing a PDZ binding motif such as Presenilin-1 (PSEN1) is blocked. Binding of these ligands might be regulated by phosphorylation of Y836 in the APBA1 PDZ-binding motif, as its mutation to glutamate releases autoinhibition and enhances the interaction of the APBA1 PDZ tandem with presenilin.

Participants:
(1) Amyloid beta A4 precursor protein-binding family A member 1 (APBA1)
(2) Presenilin-1 (PSEN1)

(1) Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.
Long et al. Nat. Struct. Mol. Biol. (2005)

(2) X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.
Lau et al. Mol. Cell. Neurosci. (2000)

Other switches involving interfaces
LIG_PDZ_Class_2 - 3 more (view)
PDZ domain (Also known as DHR or GLGF) - 45 more (view)