Switch #: SWTI000333

Switch type: Specificity

Switch subtype: Domain hiding

Description:
Binding of Ezrin via its FERM domain to the EB domain of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) results in allosteric coupling to the second PDZ domain of SLC9A3R1. This relieves the intramolecular interaction with the SLC9A3R1 PDZ-binding ligand and increases the affinity of the PDZ domain for other ligands including Catenin beta-1 (CTNNB1).

Participants:
(1) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
(2) Catenin beta-1 (CTNNB1)

(1) A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
Bhattacharya et al. J. Biol. Chem. (2010)

Other switches involving participants
Catenin beta-1 (CTNNB1) - 3 more (view)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)