Description: Binding of the PDZ-binding motif of General receptor for phosphoinositides 1-associated scaffold protein (Grasp) (Tamalin) to the Tamalin (Grasp) PDZ domain locks this protein in an auto-inhibited conformation. Binding of the PDZ-binding motif of Metabotropic glutamate receptor 5 (Grm5) to the Tamalin (Grasp) PDZ domain results in disruption of the weaker intramolecular Tamalin (Grasp) interactions. The PDZ-binding motif of Tamalin (Grasp) becomes available to interact with the PDZ domain of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Magi2) (S-SCAM), which functions as a receptor for kinesin motor proteins. See also switch details.
Participants: (1) Metabotropic glutamate receptor 5 (Grm5) (2) General receptor for phosphoinositides 1-associated scaffold protein (Grasp)
(1) Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.Sugi et al. EMBO J. (2007)
Other switches involving participantsGeneral receptor for phosphoinositides 1-associated scaffold protein (Grasp) - 1 more (view)Other switches involving interfacesPDZ domain (Also known as DHR or GLGF) - 45 more (view)LIG_PDZ_Class_1 - 41 more (view)
