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Switch #:
SWTI000335
Switch type:
Specificity
Switch subtype:
Competition

Description:
The integrin regulator Talin-1 (TLN1) and the actin-crosslinking Filamins Filamin-A (FLNA) use overlapping binding sites on the cytoplasmic tails of beta integrin subunits Integrin beta-7 (ITGB7), which makes their interaction with beta integrin mutually exclusive.

Participants:
(1) Integrin beta-7 (ITGB7)
(2) Talin-1 (TLN1)
(3) Filamin-A (FLNA)

Interactions
Interaction #1 ITGB7 - TLN1

Is mutually exclusive with Interaction #2 ITGB7 - FLNA

Interfaces
(1) ELM:LIG_Talin motif (770WKQDSNPLYK779) in Integrin beta-7 (ITGB7)
(2) PTB domain (IRS-1 type) (310-401) in Talin-1 (TLN1)

Interaction Regulation
Effector binding Inhibition (Filamin-A (FLNA)) of the Integrin beta-7 (ITGB7) LIG_Talin motif - Talin-1 (TLN1) PTB domain (IRS-1 type) interaction

Interaction #2 ITGB7 - FLNA

Is mutually exclusive with Interaction #1 ITGB7 - TLN1

Interfaces
(3) ELM:LIG_Filamin motif (776PLYKSAITTTIN787) in Integrin beta-7 (ITGB7)
(4) Filamin/ABP280 repeat (2235-2322) in Filamin-A (FLNA)

Interaction Regulation
Effector binding Inhibition (Talin-1 (TLN1)) of the Integrin beta-7 (ITGB7) LIG_Filamin motif - Filamin-A (FLNA) Filamin/ABP280 repeat interaction

Additional Information
Structural information: 2BRQ
Context
References

(1) The molecular basis of filamin binding to integrins and competition with talin.
Kiema et al. Mol. Cell (2006)

See also

Other switches involving participants
Talin-1 (TLN1) - 3 more (view)
Filamin-A (FLNA) - 2 more (view)

Other switches involving interfaces
PTB domain (IRS-1 type) - 12 more (view)
ELM:LIG_Filamin - 1 more (view)
Filamin/ABP280 repeat - 3 more (view)
ELM:LIG_Talin - 2 more (view)




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