Switches.ELM

Switch #:

SWTI000335

Switch type:
Specificity

Switch subtype:
Competition

Description:
The integrin regulator Talin-1 (TLN1) and the actin-crosslinking Filamins Filamin-A (FLNA) use overlapping binding sites on the cytoplasmic tails of beta integrin subunits Integrin beta-7 (ITGB7), which makes their interaction with beta integrin mutually exclusive.

Participants:
(1) Integrin beta-7 (ITGB7)
(2) Talin-1 (TLN1)
(3) Filamin-A (FLNA)

Interactions

Interaction #1 ITGB7 - TLN1

Is mutually exclusive with Interaction #2 ITGB7 - FLNA

Interfaces
(1) ELM:LIG_Talin motif (₇₇₀WKQDSNPLYK₇₇₉) in Integrin beta-7 (ITGB7)
(2) PTB domain (IRS-1 type)_(310-401) in Talin-1 (TLN1)

Interaction Regulation
Effector binding Inhibition (Filamin-A (FLNA)) of the Integrin beta-7 (ITGB7) LIG_Talin motif - Talin-1 (TLN1) PTB domain (IRS-1 type) interaction

Interaction #2 ITGB7 - FLNA

Is mutually exclusive with Interaction #1 ITGB7 - TLN1

Interfaces
(3) ELM:LIG_Filamin motif (₇₇₆PLYKSAITTTIN₇₈₇) in Integrin beta-7 (ITGB7)
(4) Filamin/ABP280 repeat_(2235-2322) in Filamin-A (FLNA)

Interaction Regulation
Effector binding Inhibition (Talin-1 (TLN1)) of the Integrin beta-7 (ITGB7) LIG_Filamin motif - Filamin-A (FLNA) Filamin/ABP280 repeat interaction

Additional Information
Structural information: 2BRQ

Context

Switch localisation
Curated: cytoplasmic side of plasma membrane

Inferred: actin cytoskeleton, cytosol, extracellular region

Switch pathways

Inferred: Focal adhesion

References

(1) The molecular basis of filamin binding to integrins and competition with talin.
Kiema et al. Mol. Cell (2006)