Switches.ELM

Switch #:

SWTI000336

Switch type:
Specificity

Switch subtype:
Competition

Description:
The Transducin-like enhancer protein 1 (TLE1) can recruit a wide range of transcriptional repressors via its WD domain, to which the WRPW motif of Transcription factor HES-1 (HES1) and the EH1 motif of Homeobox protein goosecoid (GSC) can bind using overlapping sites.

Participants:
(1) Transcription factor HES-1 (HES1)
(2) Transducin-like enhancer protein 1 (TLE1)
(3) Homeobox protein goosecoid (GSC)

Interactions

Interaction #1 HES1 - TLE1

Is mutually exclusive with Interaction #2 GSC - TLE1

Interfaces
(1) LIG_WRPW_1 motif (₂₇₅WRPWRN₂₈₀) in Transcription factor HES-1 (HES1)
(2) WD domain, G-beta repeat_(477-767) in Transducin-like enhancer protein 1 (TLE1)

Interaction Regulation
Effector binding Inhibition (Homeobox protein goosecoid (GSC)) of the Transcription factor HES-1 (HES1) LIG_WRPW_1 motif - Transducin-like enhancer protein 1 (TLE1) WD domain, G-beta repeat interaction

Additional Information
Structural information: 2CE9

Interaction #2 GSC - TLE1

Is mutually exclusive with Interaction #1 HES1 - TLE1

Interfaces
(3) LIG_EH1_1 motif (₅MFSIDNILA₁₃) in Homeobox protein goosecoid (GSC)
(4) WD domain, G-beta repeat_(477-767) in Transducin-like enhancer protein 1 (TLE1)

Interaction Regulation
Effector binding Inhibition (Transcription factor HES-1 (HES1)) of the Homeobox protein goosecoid (GSC) LIG_EH1_1 motif - Transducin-like enhancer protein 1 (TLE1) WD domain, G-beta repeat interaction

Additional Information
Structural information: 2CE8

Context

References

(1) Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor.
Jennings et al. Mol. Cell (2006)