Switches.ELM

Switch #:

SWTI000337

Switch type:
Specificity

Switch subtype:
Competition

Description:
T-cell surface antigen CD2 (CD2) uses overlapping motifs to bind to CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) and Fyn, which makes their interactions mutually exclusive. Since CD2BP2 and Tyrosine-protein kinase Fyn (FYN) reside in different subcellular locations, the specificity of CD2 for the two competitors is switched by changing its cellular localization, from non-raft membranes to lipid raft membranes.

Participants:
(1) T-cell surface antigen CD2 (CD2)
(2) CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2)
(3) Tyrosine-protein kinase Fyn (FYN)

Interactions

Interaction #1 CD2 - CD2BP2

Is mutually exclusive with Interaction #2 CD2 - FYN

Interfaces
(1) LIG_GYF motif (₂₉₅HRPPPPGHR₃₀₃) in T-cell surface antigen CD2 (CD2)
(2) GYF domain_(281-338) in CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2)

Interaction Regulation
Effector binding Inhibition (Tyrosine-protein kinase Fyn (FYN)) of the T-cell surface antigen CD2 (CD2) LIG_GYF motif - CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) GYF domain interaction

Additional Information
Structural information: 1L2Z

Interaction #2 CD2 - FYN

Is mutually exclusive with Interaction #1 CD2 - CD2BP2

Interfaces
(3) LIG_SH3_3 motif (₂₉₄SHRPPPP₃₀₀) in T-cell surface antigen CD2 (CD2)
(4) SH3 domain_(88-135) in Tyrosine-protein kinase Fyn (FYN)

Interaction Regulation
Effector binding Inhibition (CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2)) of the T-cell surface antigen CD2 (CD2) LIG_SH3_3 motif - Tyrosine-protein kinase Fyn (FYN) SH3 domain interaction

Context

References

(1) Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.
Freund et al. EMBO J. (2002)