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Switch #:
SWTI000561
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Glutamate receptor, ionotropic kainate 1 (Grik1), abrogating binding to Glutamate receptor-interacting protein 1 (Grip1). The ER retention of Grik1 splice variants can be inhibited by PKC phosphorylation and association with a PDZ domain-containing protein. Also shown that the PDZ-binding containing proteins PSD95 and syntenin are able to bind.

Participants:
(1) Glutamate receptor, ionotropic kainate 1 (Grik1)
(2) Glutamate receptor-interacting protein 1 (Grip1)

Interactions
Interaction #1 Grik1 - Grip1

Interfaces
(1) LIG_PDZ_Class_1 motif (900LSFNAI905) in Glutamate receptor, ionotropic kainate 1 (Grik1)
(2) PDZ domain (Also known as DHR or GLGF) (471-560) and (572-657) and (672-754) and (988-1070) in Glutamate receptor-interacting protein 1 (Grip1)

Interaction Regulation
Alternative splicing Abrogation of the Glutamate receptor, ionotropic kainate 1 (Grik1) LIG_PDZ_Class_1 motif - Glutamate receptor-interacting protein 1 (Grip1) PDZ domain (Also known as DHR or GLGF) interaction

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane
Inferred: postsynaptic membrane, neuronal cell body, cell junction
References

(1) Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.
Hirbec et al. Neuron (2003)

See also

Other switches involving participants
Glutamate receptor, ionotropic kainate 1 (Grik1) - 1 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)


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