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Switch #:
SWTI000577
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of Protein PML (PML), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.

Participants:
(1) Protein PML (PML)
(2) Exportin-1 (XPO1)

Interactions
Interaction #1 PML - XPO1

Interfaces
(1) TRG_NES_CRM1_1 motif (702EAISGFLAALPLIRE716) in Protein PML (PML)
(2) Exportin 1-like protein (123-268) in Exportin-1 (XPO1)

Interaction Regulation
Alternative splicing Abrogation of the Protein PML (PML) TRG_NES_CRM1_1 motif - Exportin-1 (XPO1) Exportin 1-like protein interaction

Context
References

(1) A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals.
Henderson et al. Exp. Cell Res. (2000)

(2) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Fagioli et al. Oncogene (1992)

(3) Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.
Jul-Larsen et al. BMC Mol. Biol. (2010)

See also

Other switches involving participants
Protein PML (PML) - 9 more (view)
Exportin-1 (XPO1) - 7 more (view)

Other switches involving interfaces
TRG_NES_CRM1_1 - 3 more (view)
Exportin 1-like protein - 9 more (view)




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