Switch #: SWTI000577

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the nuclear export signal (NES) of Protein PML (PML), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.

Participants:
(1) Protein PML (PML)
(2) Exportin-1 (XPO1)

(1) A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals.
Henderson et al. Exp. Cell Res. (2000)

(2) Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Fagioli et al. Oncogene (1992)

(3) Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein.
Jul-Larsen et al. BMC Mol. Biol. (2010)

Other switches involving participants
Protein PML (PML) - 9 more (view)
Exportin-1 (XPO1) - 7 more (view)

Other switches involving interfaces
TRG_NES_CRM1_1 - 3 more (view)
Exportin 1-like protein - 9 more (view)