Switch #: SWTI000579

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the type 1 peroxisomal targeting signal (PTS1) of Alpha-methylacyl-CoA racemase (AMACR), abrogating binding to Peroxisomal targeting signal 1 receptor (PEX5) and import into the peroxisome. Only the major AMACR IA (also known as Isoform 1 of Alpha-methylacyl-CoA racemase (AMACR)) form localises to the peroxisome.

Participants:
(1) Alpha-methylacyl-CoA racemase (AMACR)
(2) Peroxisomal targeting signal 1 receptor (PEX5)

(1) Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer.
Mubiru et al. Gene (2004)

Other switches involving interfaces
Tetratricopeptide repeat - 8 more (view)