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Switch #:
SWTI000579
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the type 1 peroxisomal targeting signal (PTS1) of Alpha-methylacyl-CoA racemase (AMACR), abrogating binding to Peroxisomal targeting signal 1 receptor (PEX5) and import into the peroxisome. Only the major AMACR IA (also known as Isoform 1 of Alpha-methylacyl-CoA racemase (AMACR)) form localises to the peroxisome.

Participants:
(1) Alpha-methylacyl-CoA racemase (AMACR)
(2) Peroxisomal targeting signal 1 receptor (PEX5)

Interactions
Context
References

(1) Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer.
Mubiru et al. Gene (2004)

See also

Other switches involving interfaces
Tetratricopeptide repeat - 8 more (view)




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