Description: Alternative splicing removes the VHL-hydroxyproline-modified binding motif of Hypoxia-inducible factor 3-alpha (HIF3A), abrogating binding to Von Hippel-Lindau disease tumor suppressor (VHL). Other studies have shown that the HIF-3 alpha-4 splice variant (Isoform HIF-3alpha4 of Hypoxia-inducible factor 3-alpha (HIF3A)) can act as a dominant negative form with tumour-suppressive activity (see Maynard et al. (2007) (here)).
Participants: (1) Hypoxia-inducible factor 3-alpha (HIF3A) (2) Von Hippel-Lindau disease tumor suppressor (VHL)
(1) Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.Maynard et al. J. Biol. Chem. (2003)
Other switches involving participantsVon Hippel-Lindau disease tumor suppressor (VHL) - 5 more (view)Hypoxia-inducible factor 3-alpha (HIF3A) - 1 more (view)Other switches involving interfacesDEG_ODPH_VHL_1 - 5 more (view)von Hippel-Lindau disease tumour suppressor protein - 5 more (view)
