Switch #: SWTI000582

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the regulatory Y694 residue of Signal transducer and activator of transcription 5A (STAT5A). The phosphorylation of Y694 by Proto-oncogene tyrosine-protein kinase Src (SRC) has been shown to be essential for DNA binding. This event acts as an important regulatory mechanism (See Clark et al. (2005) (here) and Okutani et al. (2001) (here)). The exact function of Y694 remains uncertain as is binding to STAT5 in dimer. The STAT5A-DeltaE18 does not enter nucleus upon PRLR stimulation.

Participants:
(1) Signal transducer and activator of transcription 5A (STAT5A)

(1) A novel splicing variant form suppresses the activity of full-length signal transducer and activator of transcription 5A.
Watanabe et al. FEBS J. (2009)

Other switches involving participants
Signal transducer and activator of transcription 5A (STAT5A) - 3 more (view)

Other switches involving interfaces
LIG_SH2_STAT5 - 7 more (view)
SH2 domain - 140 more (view)