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Switch #:
SWTI000583
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the 14-3-3-binding motif of Isoform Short of Huntingtin-associated protein 1 (Hap1), abrogating binding to 14-3-3 protein zeta/delta (Ywhaz). The association of HAP1A (Isoform Short of Huntingtin-associated protein 1 (Hap1)) with 14-3-3 protein zeta/delta (Ywhaz) inhibits binding of the splice variant to members of the kinesin light chain family and diminishes trafficking of Hap1 to neural processes and neurite tips. The result is a decrease in neurite outgrowth.

Participants:
(1) Isoform Short of Huntingtin-associated protein 1 (Hap1)
(2) 14-3-3 protein zeta/delta (Ywhaz)

Interactions
Interaction #1 Hap1 - Ywhaz

Interfaces
(1) ELM:LIG_14-3-3_4 motif (594YRSST598) in Isoform Short of Huntingtin-associated protein 1 (Hap1)
(2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (Ywhaz)

Interaction Regulation
Alternative splicing Abrogation of the Isoform Short of Huntingtin-associated protein 1 (Hap1) LIG_14-3-3_4 motif - 14-3-3 protein zeta/delta (Ywhaz) 14-3-3 protein interaction

Context
References

(1) 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
Rong et al. J. Biol. Chem. (2007)

See also

Other switches involving interfaces
14-3-3 protein - 38 more (view)
ELM:LIG_14-3-3_4 - 1 more (view)




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