switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O00213 (3 hits) x

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Curated inferred

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Evidence

Cyclin-dependent kinase 1 - CDK1 - Homo sapiens
LIG_PTB_Apo_2	A4_HUMAN	756	763	Binary	Physicochemical compatibility	Phosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).	details	Inferred
Glycogen synthase kinase-3 beta - GSK3B - Homo sapiens
LIG_PTB_Apo_2	A4_HUMAN	756	763	Binary	Physicochemical compatibility	Phosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_PTB_Apo_2	A4_HUMAN	756	763	Specificity	Altered binding specificity	Phosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).	details	Inferred