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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:O00213 (3 hits) x


x  Coloured by: Modifier evidence source
          Curated          inferred


x  Index
Cyclin-dependent kinase 1Glycogen synthase kinase-3 betaTyrosine-protein kinase Fyn


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Cyclin-dependent kinase 1 - CDK1 -  Homo sapiens
LIG_PTB_Apo_2 A4_HUMAN756763BinaryPhysicochemical compatibilityPhosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).
details
Inferred

Glycogen synthase kinase-3 beta - GSK3B -  Homo sapiens
LIG_PTB_Apo_2 A4_HUMAN756763BinaryPhysicochemical compatibilityPhosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).
details
Inferred

Tyrosine-protein kinase Fyn - FYN -  Homo sapiens
LIG_PTB_Apo_2 A4_HUMAN756763SpecificityAltered binding specificityPhosphorylation of Y757 in APP (Amyloid beta A4 protein (APP)) switches its specificity from PTB domain containing proteins, like Amyloid beta A4 precursor protein-binding family B member 1 (APBB1), which is involved in trafficking and processing of APP, to SH2 domain containing proteins, such as Growth factor receptor-bound protein 2 (GRB2).
details
Inferred
           
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