switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O70161 (4 hits) x

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Curated inferred

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Information

Evidence

Cyclin-dependent kinase 5 - CDK5 - Mus musculus
LIG_PTB_Talin	PI51C_MOUSE	645	648	Binary	Physicochemical compatibility	Phosphorylation of S645 in the PTB-binding motif of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) by Cyclin-dependent kinase 5 (Cdk5) inhibits its interaction with Talin-1 (Tln1).	details	Curated
TRG_AP2beta_CARGO_2	PI51C_MOUSE	633	644	Binary	Physicochemical compatibility	Phosphorylation of S645 in Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) impedes binding to AP-2 complex subunit beta (Ap2b1), while dephosphorylation by calcineurin promotes binding. These phosphorylation and dephosphorylation events are important for the regulation of clathrin coat formation associated with synaptic vesicles.	details	Curated
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_PTB_Talin	PI51C_MOUSE	645	648	Binary	Physicochemical compatibility	Phosphorylation of Y644 in Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) promotes its association with Talin-1 (Tln1).	details	Inferred
LIG_PTB_Talin	PI51C_MOUSE	645	648	Binary	Physicochemical compatibility	Phosphorylation of Y644 in Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) promotes its association with Talin-1 (Tln1).	details	Inferred