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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P53350 (5 hits) x
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x  Coloured by: Modifier evidence source
          Curated          inferred


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Cyclin-dependent kinase 1Serine/threonine-protein kinase PLK1Serine/threonine-protein kinase PLK3


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Cyclin-dependent kinase 1 - CDK1 -  Homo sapiens
LIG_PLK MPIP3_HUMAN129131BinaryPhysicochemical compatibilityPhosphorylation of T130 in the PLK-docking motif of M-phase inducer phosphatase 3 (CDC25C) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates M-phase inducer phosphatase 3 (CDC25C). This results in inactivation of the NES of M-phase inducer phosphatase 3 (CDC25C), thereby promoting its nuclear localization.
details
Curated
LIG_PLK MPIP2_HUMAN4951BinaryPhysicochemical compatibilityPhosphorylation of S50 in the PLK-docking motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates and activates M-phase inducer phosphatase 2 (CDC25B).
details
Curated

Serine/threonine-protein kinase PLK1 - PLK1 -  Homo sapiens
TRG_NES_CRM1_1 MPIP3_HUMAN189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details
Curated

Serine/threonine-protein kinase PLK3 - PLK3 -  Homo sapiens
TRG_NES_CRM1_1 MPIP3_HUMAN189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details
Inferred
TRG_NES_CRM1_1 MPIP3_HUMAN189203BinaryPhysicochemical compatibilityPhosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).
details
Inferred
           
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