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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: UNIPROT:P17612 (2 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
  Uncategorised  Rheostatic  Allostery  Avidity-sensing
  Physicochemical compatibility  Pre-translational  Competition

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MOD_NMyristoylMOD_PKA_2


ProteinStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

MOD_NMyristoyl - Generic motif for N-Myristoylation site.
KAPCA_HUMAN17BinaryAllosteryPhosphorylation of cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) at S11 shifts the conformational equilibrium to the myristoyl-out conformation, making the myristoyl moiety available for interaction with the membrane.
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MOD_PKA_2 - Secondary preference for PKA-type AGC kinase phosphorylation.
SPTB2_HUMAN21572162BinaryPre‑translationalAlternative splicing removes the PKA-binding motif of Isoform Short of Spectrin beta chain, brain 1 (SPTBN1), abrogating binding to cAMP-dependent protein kinase catalytic subunit alpha (PRKACA). The phosphorylation of the short C-terminal betaII-spectrin (also known as Isoform Short of Spectrin beta chain, brain 1 (SPTBN1)) by PKA is important in allowing neuritogenesis.
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