Please send any suggestions/comments to: switches@elm.eu.org
| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Spectrin beta chain, brain 1 - SPTBN1 - Homo sapiens | |||||||
| MOD_PKA_2 | 2157 | 2162 | Binary | Pre‑translational | Alternative splicing removes the PKA-binding motif of Isoform Short of Spectrin beta chain, brain 1 (SPTBN1), abrogating binding to cAMP-dependent protein kinase catalytic subunit alpha (PRKACA). The phosphorylation of the short C-terminal betaII-spectrin (also known as Isoform Short of Spectrin beta chain, brain 1 (SPTBN1)) by PKA is important in allowing neuritogenesis. | ||
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Homo sapiens | |||||||
| MOD_NMyristoyl | 1 | 7 | Binary | Allostery | Phosphorylation of cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) at S11 shifts the conformational equilibrium to the myristoyl-out conformation, making the myristoyl moiety available for interaction with the membrane. | ||