switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_Filamin (3 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Focal adhesion (KEGG - hsa04510)
LIG_Filamin	ITB7_HUMAN	776	787	Specificity	Competition	The integrin regulator Talin-1 (TLN1) and the actin-crosslinking Filamins Filamin-A (FLNA) use overlapping binding sites on the cytoplasmic tails of beta integrin subunits Integrin beta-7 (ITGB7), which makes their interaction with beta integrin mutually exclusive.	details	Inferred
LIG_Filamin_2	ITB1_HUMAN	783	791	Binary	Pre‑translational	Alternative splicing strongly inhibits the binding of the filamin-binding motif of Integrin beta-1 (ITGB1) to Filamin-A (FLNA), primarily due to the alteration of A to P it seems.	details	Inferred
LIG_Filamin_2	ITB1_HUMAN	783	791	Binary	Pre‑translational	Alternative splicing strongly inhibits the binding of the filamin-binding motif of Integrin beta-1 (ITGB1) to Filamin-B (FLNB), primarily due to the alteration of A to P it seems. Splicing of FLNB also affects this interaction.	details	Inferred