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Filtered:
PFAM:PF00928 (4 hits)
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inferred
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Index
Endocytosis
Endocytosis
Motif
Protein
Start
End
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Information
Evidence
Endocytosis
(
KEGG - hsa04144
)
TRG_ENDOCYTIC_2
EGFR_HUMAN
998
1001
Binary
Allostery
Binding of
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the
AP-2 complex subunit mu (AP2M1)
subunit for recruitment of
Epidermal growth factor receptor (EGFR)
via an endocytosis motif.
details
Inferred
TRG_ENDOCYTIC_2
TFR1_HUMAN
20
23
Binary
Allostery
Binding of
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the
AP-2 complex subunit mu (AP2M1)
subunit for recruitment of
Transferrin receptor protein 1 (TFRC)
via an endocytosis motif.
details
Inferred
TRG_ENDOCYTIC_2
PI51C_HUMAN
649
652
Binary
Physicochemical compatibility
Phosphorylation of S645 near the AP2-binding motif of
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C)
by
Cyclin-dependent kinase 5 (Cdk5)
inhibits its interaction with
AP-2 complex subunit mu (AP2M1)
.
details
Inferred
Endocytosis
(
KEGG - mmu04144
)
TRG_ENDOCYTIC_2
PI51C_MOUSE
644
647
Binary
Pre‑translational
Alternative splicing removes the endocytosis motif of
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c)
, abrogating binding to
AP-2 complex subunit mu (Ap2m1)
. The direct interaction between the AP-2 complex and
Isoform PIPKIgamma661 of Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c)
(PIPKIgamma661) targets this isoform to sites of endocytosis at the plasma membrane. Consequently, this results in the generation of a highly concentrated pool of PI(4,5)P2 at these sites.
details
Inferred
