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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Focal adhesion (KEGG - hsa04510) | ||||||||
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Binary | Physicochemical compatibility | Phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to the SHC-transforming protein 1 (SHC1) protein. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Binary | Physicochemical compatibility | Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1). | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Cumulative | Rheostatic | While phosphorylation of Y785 in the PTB-binding motif of Integrin beta-3 (ITGB3) induces binding to SHC-transforming protein 1 (SHC1), additional phosphorylation of Y773 further increases the strength of the interaction. | Inferred | |
| LIG_PTB_Apo_2 | ITB3_HUMAN | 767 | 774 | Specificity | Altered binding specificity | Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation. | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 767 | 773 | Specificity | Altered binding specificity | Phosphorylation of Y773 in Integrin beta-3 (ITGB3) switches the specificity of ITGB3 from Talin-1 (TLN1) to Docking protein 1 (DOK1), with a 2-fold decrease of the affinity for TLN1 and close to a 400-fold increase of the affinity for DOK1. This switch results in negative regulation of integrin activation. | Inferred | |
| LIG_PTB_Apo_2 | ITB3_HUMAN | 779 | 786 | Specificity | Altered binding specificity | Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1). | Inferred | |
| LIG_PTB_Phospho_1 | ITB3_HUMAN | 779 | 785 | Specificity | Altered binding specificity | Phosphorylation of Integrin beta-3 (ITGB3) at Y785 switches the specificity of integrin from Kindlin-2 (Fermitin family homolog 2 (FERMT2)) to the adaptor protein SHC-transforming protein 1 (SHC1). | Inferred | |