switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P07766 (3 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH3_5	CD3E_HUMAN	184	188	Binary	Allostery	Ligand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation.	details	Inferred
LIG_SH3_5	CD3E_HUMAN	184	188	Specificity	Altered binding specificity	Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred
LIG_TYR_ITAM	CD3E_HUMAN	185	202	Specificity	Altered binding specificity	Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).	details	Inferred