About Help Definitions Submit Search Analyse Browse Home


Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P07766 (3 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
T cell receptor signaling pathway


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

T cell receptor signaling pathway (KEGG - hsa04660)
LIG_SH3_5 CD3E_HUMAN184188BinaryAllosteryLigand binding to the T cell receptor complex TCR-CD3 results in a conformational change that exposes an SH3-binding motif in T-cell surface glycoprotein CD3 epsilon chain (CD3E), resulting in recruitment of Cytoplasmic protein NCK2 (NCK2), involved in T cell activation.
details
Inferred
LIG_SH3_5 CD3E_HUMAN184188SpecificityAltered binding specificityPhosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Inferred
LIG_TYR_ITAM CD3E_HUMAN185202SpecificityAltered binding specificityPhosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Inferred
           
Please send any suggestions/comments to: switches@elm.eu.org