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UNIPROT:P30307 (4 hits)
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Pathway evidence source
Curated
inferred
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Index
Cell cycle
G2/M Transition
Motif
Protein
Start
End
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Information
Evidence
Cell cycle
(
KEGG - hsa04110
)
LIG_PLK
MPIP3_HUMAN
129
131
Binary
Physicochemical compatibility
Phosphorylation of T130 in the PLK-docking motif of
M-phase inducer phosphatase 3 (CDC25C)
by
Cyclin-dependent kinase 1 (CDK1)
-
Cyclin AB subfamily
generates a recruitment site for
Serine/threonine-protein kinase PLK1 (PLK1)
, which then phosphorylates
M-phase inducer phosphatase 3 (CDC25C)
. This results in inactivation of the NES of
M-phase inducer phosphatase 3 (CDC25C)
, thereby promoting its nuclear localization.
details
Curated
LIG_14-3-3_3
MPIP3_HUMAN
213
218
Binary
Physicochemical compatibility
Phosphorylation of S216 in a 14-3-3-binding motif of
M-phase inducer phosphatase 3 (CDC25C)
by
Serine/threonine-protein kinase Chk1 (CHEK1)
induces binding to
14-3-3 protein beta/alpha (YWHAB)
, which negatively regulates
M-phase inducer phosphatase 3 (CDC25C)
.
details
Curated
TRG_NES_CRM1_1
MPIP3_HUMAN
189
203
Binary
Physicochemical compatibility
Phosphorylation of S198 in the NES of
M-phase inducer phosphatase 3 (CDC25C)
by
Serine/threonine-protein kinase PLK1 (PLK1)
inhibits binding to
Exportin-1 (XPO1)
, thus promoting nuclear localization of
M-phase inducer phosphatase 3 (CDC25C)
.
details
Curated
G2/M Transition
(
Reactome - 69275
)
TRG_NES_CRM1_1
MPIP3_HUMAN
189
203
Binary
Physicochemical compatibility
Phosphorylation of S198 in the NES of
M-phase inducer phosphatase 3 (CDC25C)
by
Serine/threonine-protein kinase PLK1 (PLK1)
inhibits binding to
Exportin-1 (XPO1)
, thus promoting nuclear localization of
M-phase inducer phosphatase 3 (CDC25C)
.
details
Curated
