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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Recoverin (Bos) | cAMP-dependent protein kinase catalytic subunit alpha | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Recoverin - RCVRN - Bos taurus | |||||||
| MOD_NMyristoyl | 1 | 7 | Binary | Allostery | Binding of calcium(2+) to Recoverin (RCVRN) results in a conformational change in Recoverin that makes the myristoyl moiety available for binding to the membrane. | ||
cAMP-dependent protein kinase catalytic subunit alpha - PRKACA - Homo sapiens | |||||||
| MOD_NMyristoyl | 1 | 7 | Binary | Allostery | Phosphorylation of cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) at S11 shifts the conformational equilibrium to the myristoyl-out conformation, making the myristoyl moiety available for interaction with the membrane. | ||
cGMP-dependent 3',5'-cyclic phosphodiesterase - PDE2A - Homo sapiens | |||||||
| MOD_NMyristoyl | 1 | 7 | Binary | Pre‑translational | Alternative splicing removes the myristoylation motif of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A). The soluble Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) is expressed in a variety of peripheral tissues, whereas the membrane-associated Isoform PDE2A3 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) is found exclusively in the brain. Isoform PDE2A3 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A) requires N-myristoylation together with palmitoylation to be targeted to synapses, allowing control and crosstalk of cyclic nucleotides. | ||