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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Glutamate receptor ionotropic, kainate 1 (Rattus) | Glutamate receptor, ionotropic kainate 1 (Rattus) |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Glutamate receptor ionotropic, kainate 1 - Grik1 - Rattus norvegicus | |||||||
| LIG_PDZ_Class_1 | 900 | 905 | Binary | Pre‑translational | Alternative splicing removes the PDZ-binding motif of Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1 (Grik1), abrogating binding to PRKCA-binding protein (Pick1). The ER-retention motif of Grik1 splice variants can be inhibited by PKC phosphorylation and association with a PDZ protein. It has also been shown that the PDZ domain-containing proteins Disks large homolog 4 (Dlg4) and Syntenin-1 (Sdcbp) are able to bind. | ||
Glutamate receptor, ionotropic kainate 1 - Grik1 - Rattus norvegicus | |||||||
| LIG_PDZ_Class_1 | 900 | 905 | Binary | Pre‑translational | Alternative splicing removes the PDZ-binding motif of Glutamate receptor, ionotropic kainate 1 (Grik1), abrogating binding to Glutamate receptor-interacting protein 1 (Grip1). The ER retention of Grik1 splice variants can be inhibited by PKC phosphorylation and association with a PDZ domain-containing protein. Also shown that the PDZ-binding containing proteins PSD95 and syntenin are able to bind. | ||
| TRG_ER_diArg_2 | 937 | 941 | Binary | Pre‑translational | Alternative splicing removes the di-arginine ER-retention motif of Glutamate receptor, ionotropic kainate 1 (Grik1), abrogating binding to Coatomer subunit beta (COPB1). | ||