switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: UNIPROT:P04637 (2 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Casein kinase I subfamily
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Physicochemical compatibility	Phosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.	details	Curated
DNA-dependent protein kinase catalytic subunit - PRKDC - Homo sapiens
MOD_GSK3_1	P53_HUMAN	30	37	Binary	Physicochemical compatibility	Phosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).	details	Curated