switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: UNIPROT:P30307 (3 hits) x

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Curated inferred

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Protein

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Information

Evidence

Cyclin-dependent kinase 1 - CDK1 - Homo sapiens
LIG_PLK	MPIP3_HUMAN	129	131	Binary	Physicochemical compatibility	Phosphorylation of T130 in the PLK-docking motif of M-phase inducer phosphatase 3 (CDC25C) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates M-phase inducer phosphatase 3 (CDC25C). This results in inactivation of the NES of M-phase inducer phosphatase 3 (CDC25C), thereby promoting its nuclear localization.	details	Curated
Serine/threonine-protein kinase Chk1 - CHEK1 - Homo sapiens
LIG_14-3-3_3	MPIP3_HUMAN	213	218	Binary	Physicochemical compatibility	Phosphorylation of S216 in a 14-3-3-binding motif of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase Chk1 (CHEK1) induces binding to 14-3-3 protein beta/alpha (YWHAB), which negatively regulates M-phase inducer phosphatase 3 (CDC25C).	details	Curated
Serine/threonine-protein kinase PLK1 - PLK1 - Homo sapiens
TRG_NES_CRM1_1	MPIP3_HUMAN	189	203	Binary	Physicochemical compatibility	Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C).	details	Curated