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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: ELM:LIG_SH3_5 (2 hits) x


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Tyrosine-protein kinase Fyn


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Tyrosine-protein kinase Fyn - FYN -  Homo sapiens
LIG_SH3_5 CD3E_HUMAN184188SpecificityAltered binding specificityPhosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Inferred
LIG_SH3_5 CD3E_HUMAN184188SpecificityAltered binding specificityPhosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).
details
Inferred
           
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