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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: IPR:IPR008984 (12 hits) x


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          Curated          inferred


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Casein kinase II subunit alphaCasein kinase II subunit alpha'


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Casein kinase II subunit alpha - CSNK2A1 -  Homo sapiens
LIG_FHA_2 XRCC4_HUMAN231237BinaryPhysicochemical compatibilityPhosphorylation of T233 in the FHA-binding motif of DNA repair protein XRCC4 (XRCC4) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Bifunctional polynucleotide phosphatase/kinase (PNKP) protein.
details
Curated
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Curated
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Curated
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Curated
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Curated
LIG_FHA_2 XRCC1_HUMAN517523Avidity‑sensingHierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
details
Curated
LIG_FHA_2 XRCC1_HUMAN521527Avidity‑sensingHierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
details
Curated

Casein kinase II subunit alpha' - CSNK2A2 -  Homo sapiens
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Inferred
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Inferred
LIG_FHA_2 XRCC1_HUMAN517
521
523
527
CumulativeRheostaticTwo Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
details
Inferred
LIG_FHA_2 XRCC1_HUMAN517523Avidity‑sensingHierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
details
Inferred
LIG_FHA_2 XRCC1_HUMAN521527Avidity‑sensingHierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
details
Inferred
           
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