switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: ELM:LIG_SH2_IIC (2 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

Protein

Start

End

Switch Type

Switch Subtype

Switch Description

Information

LIG_SH2_IIC -
ZAP70_HUMAN	284	300	Binary	Physicochemical compatibility	Phosphorylation of Y292 in the SH2-binding motif of Tyrosine-protein kinase ZAP-70 (ZAP70) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details
KSYK_HUMAN	315	331	Binary	Physicochemical compatibility	Phosphorylation of Y323 in the SH2-binding motif of Tyrosine-protein kinase SYK (SYK) induces binding to the E3 ubiquitin-protein ligase CBL-B (CBLB) protein.	details