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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: ELM:DEG_SCF_SKP2-CKS1_1 (4 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
Cell cycleCell cycle


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

(Reactome - 2676436)
DEG_SCF_SKP2-CKS1_1 CDN1B_HUMAN183190Pre‑assemblyComposite binding site formationBinding of Cyclin-dependent kinase inhibitor 1B (CDKN1B) (p27) to the SCF-Skp2 ubiquitin ligase complex requires phosphorylation of p27 (CDKN1B) at T187, and association of the F-box protein S-phase kinase-associated protein 2 (SKP2) with the regulatory Cyclin-dependent kinases regulatory subunit 1 (CKS1B). SKP2 and CKS1B together generate a composite binding site for p27 (CDKN1B). While some residues, including the phosphorylated T187, bind to CKS1B and others to SKP2, the E185 makes contact with residues of both CKS1B and SKP2.
details
Curated

Cell cycle (KEGG - hsa04110)
DEG_SCF_SKP2-CKS1_1 CDN1B_HUMAN183190Pre‑assemblyComposite binding site formationBinding of Cyclin-dependent kinase inhibitor 1B (CDKN1B) (p27) to the SCF-Skp2 ubiquitin ligase complex requires phosphorylation of p27 (CDKN1B) at T187, and association of the F-box protein S-phase kinase-associated protein 2 (SKP2) with the regulatory Cyclin-dependent kinases regulatory subunit 1 (CKS1B). SKP2 and CKS1B together generate a composite binding site for p27 (CDKN1B). While some residues, including the phosphorylated T187, bind to CKS1B and others to SKP2, the E185 makes contact with residues of both CKS1B and SKP2.
details
Curated
DEG_SCF_SKP2-CKS1_1 CDN1C_HUMAN306313Pre‑assemblyComposite binding site formationBinding of Cyclin-dependent kinase inhibitor 1C (CDKN1C) (p57) to the SCF-Skp2 ubiquitin ligase complex requires phosphorylation of p57 (CDKN1C) at T310, and association of the F-box protein S-phase kinase-associated protein 2 (SKP2) with the regulatory Cyclin-dependent kinases regulatory subunit 1 (CKS1B). SKP2 and CKS1B together generate a composite binding site for p57 (CDKN1C).
details
Curated

Cell cycle (KEGG - mmu04110)
DEG_SCF_SKP2-CKS1_1 CDN1C_MOUSE338345Pre‑assemblyComposite binding site formationBinding of Cyclin-dependent kinase inhibitor 1C (Cdkn1c) (p57) to the SCF-Skp2 ubiquitin ligase complex requires phosphorylation of p57 (Cdkn1c) at T342, and association of the F-box protein S-phase kinase-associated protein 2 (SKP2) with the regulatory Cyclin-dependent kinases regulatory subunit 1 (CKS1B). SKP2 and CKS1B together generate a composite binding site for p57 (Cdkn1c).
details
Curated
           
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