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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: PFAM:PF01602 (5 hits) x


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          Curated          inferred


x  Index
GABAergic synapseGlutamatergic synapseNeuroactive ligand-receptor interaction


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

GABAergic synapse (KEGG - hsa04727)
TRG_ER_diArg_1 GABR1_HUMAN923926SpecificityMotif hidingInteraction of the GABA receptor R2 subunit (Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)) with the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)) via coiled-coil forming domains masks the ER retention motif in the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)), thereby promoting surface expression of fully assembled GABA receptors.
details
Inferred

Glutamatergic synapse (KEGG - hsa04724)
TRG_ER_diArg_1 NMDZ1_HUMAN893895SpecificityMotif hidingBinding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.
details
Inferred
TRG_ER_diArg_1 NMDZ1_HUMAN893895SpecificityMotif hidingBinding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.
details
Inferred
TRG_ER_diArg_1 NMDZ1_HUMAN893895SpecificityMotif hidingBinding of the PDZ domain of Disks large homolog 4 (DLG4) suppresses the ER-retention motif of Isoform 4 of Glutamate receptor subunit zeta-1 (GRIN1) in a splice variant-specific manner, thereby promoting cell surface expression of this particular isoform. This supports the hypothesis that local regulation of receptor exit from neuronal ER plays a role in modifying discrete synaptic receptor number.
details
Inferred

Neuroactive ligand-receptor interaction (KEGG - hsa04080)
TRG_ER_diArg_1 GABR1_HUMAN923926SpecificityMotif hidingInteraction of the GABA receptor R2 subunit (Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)) with the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)) via coiled-coil forming domains masks the ER retention motif in the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)), thereby promoting surface expression of fully assembled GABA receptors.
details
Inferred
           
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