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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:P21333 (3 hits) x


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Focal adhesion


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Focal adhesion (KEGG - hsa04510)
LIG_Talin ITB7_HUMAN770779SpecificityCompetitionThe integrin regulator Talin-1 (TLN1) and the actin-crosslinking Filamins Filamin-A (FLNA) use overlapping binding sites on the cytoplasmic tails of beta integrin subunits Integrin beta-7 (ITGB7), which makes their interaction with beta integrin mutually exclusive.
details
Inferred
LIG_Filamin ITB7_HUMAN776787SpecificityCompetitionThe integrin regulator Talin-1 (TLN1) and the actin-crosslinking Filamins Filamin-A (FLNA) use overlapping binding sites on the cytoplasmic tails of beta integrin subunits Integrin beta-7 (ITGB7), which makes their interaction with beta integrin mutually exclusive.
details
Inferred
LIG_Filamin_2 ITB1_HUMAN783791BinaryPre‑translationalAlternative splicing strongly inhibits the binding of the filamin-binding motif of Integrin beta-1 (ITGB1) to Filamin-A (FLNA), primarily due to the alteration of A to P it seems.
details
Inferred
           
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