switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P40337 (7 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

HIF-1 signaling pathway

Regulation of Hypoxia-inducible Factor (HIF) by Oxygen

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

HIF-1 signaling pathway (KEGG - hsa04066)
DEG_ODPH_VHL_1	HIF1A_HUMAN	400	413	Binary	Physicochemical compatibility	Hydroxylation of P402 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
DEG_ODPH_VHL_1	HIF1A_HUMAN	562	574	Binary	Physicochemical compatibility	Hydroxylation of P564 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen (Reactome - 1234174)
DEG_ODPH_VHL_1	HIF1A_HUMAN	400	413	Binary	Physicochemical compatibility	Hydroxylation of P402 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
DEG_ODPH_VHL_1	HIF1A_HUMAN	562	574	Binary	Physicochemical compatibility	Hydroxylation of P564 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
DEG_ODPH_VHL_1	EPAS1_HUMAN	403	416	Binary	Physicochemical compatibility	Hydroxylation of P405 in the VHL-binding motif of Endothelial PAS domain-containing protein 1 (EPAS1) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
DEG_ODPH_VHL_1	EPAS1_HUMAN	529	542	Binary	Physicochemical compatibility	Hydroxylation of P531 in the VHL-binding motif of Endothelial PAS domain-containing protein 1 (EPAS1) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated
DEG_ODPH_VHL_1	HIF3A_HUMAN	490	502	Binary	Physicochemical compatibility	Hydroxylation of P492 in the VHL-binding motif of Hypoxia-inducible factor 3-alpha (HIF3A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.	details	Curated