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Group by :Switch typeMotif classProteinEnzymePathway            Group Index    Colouring Info              Filtered: ELM:LIG_PCNA_PIPBox_1 (3 hits) x
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  Domain hiding  Altered binding specificity  Motif hiding  Composite binding site formation
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  Physicochemical compatibility  Pre-translational  Competition

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Cyclin-dependent kinase inhibitor 1DNA polymerase delta subunit 3


MotifStartEndSwitch TypeSwitch SubtypeSwitch DescriptionInformation

Cyclin-dependent kinase inhibitor 1 - CDKN1A -  Homo sapiens
LIG_PCNA_PIPBox_1144153BinaryPhysicochemical compatibilityPhosphorylation of T145 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by RAC-alpha serine/threonine-protein kinase (AKT1) inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.
details
LIG_PCNA_PIPBox_1144153BinaryPhysicochemical compatibilityPhosphorylation of S146 in the PCNA-binding motif of Cyclin-dependent kinase inhibitor 1 (CDKN1A) by PKC subfamily inhibits binding to Proliferating cell nuclear antigen (PCNA). As a result, Cyclin-dependent kinase inhibitor 1 (CDKN1A) no longer inhibits Proliferating cell nuclear antigen (PCNA) and blocking of DNA replication is relieved.
details

DNA polymerase delta subunit 3 - POLD3 -  Homo sapiens
LIG_PCNA_PIPBox_1456465BinaryPhysicochemical compatibilityPhosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.
details
           
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