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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Calcium/calmodulin-dependent protein kinase type II subunit delta (Rattus) | F-box/WD repeat-containing protein 7 |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Calcium/calmodulin-dependent protein kinase type II subunit delta - Camk2d - Rattus norvegicus | |||||||
| TRG_NLS_MonoCore_2 | 327 | 332 | Binary | Pre‑translational | Alternative splicing removes the nuclear localisation signal (NLS) of Isoform Delta 3 of Calcium/calmodulin-dependent protein kinase type II subunit delta (Camk2d), abrogating binding to Importin subunit alpha-1 (KPNA1) and nuclear import. This is due to an 11 amino acid insert encoded by exon 14. | ||
F-box/WD repeat-containing protein 7 - FBXW7 - Homo sapiens | |||||||
| TRG_NLS_MonoCore_2 | 10 | 15 | Binary | Pre‑translational | Alternative splicing removes the nuclear localisation signal (NLS) of F-box/WD repeat-containing protein 7 (FBXW7), abrogating binding to Importin subunit alpha-1 (KPNA1). There are two other NLS motifs in the protein, meaning the isoform can still enter the nucleus. | ||